One advantage of subscribing to rss feeds is that you dont have to constantly revisit this site to check for updates within specific sections you might be interested in because your browser or feed reader will do this for you automatically on a regular basis plus you can even get email. Blood must remain fluid within the vasculature and yet clot quickly when exposed to subendothelial surfaces at sites of vascular injury. Download free pharmacology powerpoint templates and themes. Xiia xii thromboplastin xia xi ixa ix viia xa x factors affected by heparin prothrombin vit. These drugs are prescribed to patients to treat and prevent a variety of diseases and conditions dvt, pulmonary embolism, blood clot during atrial fibrillation. Apr 21, 20 hemorrhage is the main concerning adverse event with all anticoagulants. Chapter 11 drugs for disorders of connective tissue and the musculoskeletal system. Download pharmacology powerpoint lectures download free online book chm pdf. Each type works at a different level on the blood coagulation pathway. It is also a valuable tool for clinicians providing a description of the mode of action and management of therapy for anticoagulant drugs used in daily clinical practice in different clinical settings, including direct oral anticoagulants dabigatran, rivaroxaban. Spoken mistake in the first minute of the video the oldest drug on this video is heparin, not warfarin.
The first drugs designed to inhibit platelets or coagulation factors, such as the antiplatelet clopidogrel and the anticoagulant warfarin, significantly reduced the risk of thrombotic events at the. This can result in either inadequate or excessive drug concentrations. In older patients presenting to an emergency department with a warfarin adverse drug event, about half required hospitalization. Common side effects of these drugs are bruises, diarrhea, fever, intestinal gas, and headache. Antithrombotic drugs, which include antiplatelet and anticoagulant therapies, prevent and treat many cardiovascular disorders and, as such, are some of the most commonly prescribed drugs worldwide. Classification of anticoagulant drugs drug group sub groups route name of drugs 1 indirect thrombin inhibitors unfractionated heparin iv, sc heparin low molecular weight heparins lmwh sc enoxaparin, dalteparin, tinzaparin heparinoid sc danaparoid 2 direct thrombin inhibitors oral dabigatran, ximelagatran iv,sc hirudin, lepirudin, bivalirudin. Clinical pharmacology of antiarrhythmic drugs ischemic heart disease there are 35 risk factors for. This slide lists the various drugs that have been reported to interact with and potentate warfarin the strength of the evidence is shown in the left hand column with level i being strongest and level iv the weakest based on the study design of the report. Learn vocabulary, terms, and more with flashcards, games, and other study tools.
Files are presented courtesy of the respective instructors, used with permission. Weitz blood coagulation and anticoagulant, fibrinolytic, and antiplatelet drugs. Apr 17, 2017 pharmacology of anticoagulants, antiplatelets 1. Anticoagulants and antiplatelet drugs clinical pharmacology. Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that todays audiences expect. Choose from 500 different sets of anticoagulant drugs pharmacology anticoagulants flashcards on quizlet. With their ubiquitous use, it becomes important for clinicians to have a sound understanding of anticoagulant pharmacology, dosing, and toxicity.
Kd tripathi essentials of pharmacology free download pdf 7th edition kd tripathi essentials of pharmacology is the best basic book for pharmacology, its a must have to pass your second professional examination, although some students go for shanbag too, its also quite good, but it doesnt makeclear your concepts. Anticoagulant, antithrombotic and antiplatelet drugs free download as powerpoint presentation. Its pharmacokinetic and pharmacodynamic pkpd properties are shown in tables 1 and 2. Blood coagulation and anticoagulant, fibrinolytic, and antiplatelet drugs. Of these clotting factors, thrombin iia and activated factor x xa are believed to play the most critical role in hemostasis. Pharmacology or therapeutics lectures download book. The drugs used to inhibit thrombosis and to limit abnormal bleeding are the subjects of this chapter. Pdf pharmacology and mechanisms of action of new oral. Clinical pharmacology and therapeutics lecture notes provides a clear overview of all the key prescribing topics needed for medical finals and beyond. Weve already covered the pharmacology of injectable anticoagulants elsewhere, so here were going to deal with their oral equivalents. Anticoagulants and antiplatelet drugs classification anticoagulants parenteral heparin ufh lmwh enoxaparin tinzaparin dalteparin certoparin heparinoids danaparoid hirudins lepirudin bivalirudin pentasaccharide idraparinux fondaparinux oral warfarin acenocoumarole nicoumalone phenindione factor xa inhibitors rivaroxaban. Plateletaggregation inhibition is not significant until after approximately 4 days of regular dosing.
Anticoagulant drugs is the property of its rightful. View coagulant and anticoagulant drugs ppts online, safely and virusfree. Antithrombotic drugs used to treat thrombosis include antiplatelet drugs, which inhibit platelet activation or aggregation. Understanding of the pharmacology of thrombolytics, anticoagulants, and antiplatelets is critical to performing safe and effective endovascular therapy for acute ischemic therapy. Customize your medscape account with the health plans you accept, so that the information you need is saved and ready every time you look up a drug on our site or in the medscape app. View and download powerpoint presentations on classification of anticoagulants ppt. Anticoagulants drugs that help prevent the clotting coagulation of blood. Pharmacology 120 julie cordts instructor pharmacology powerpoint lectures all lessons will open in a new browser window allowing easy access to this menu. Heparin was the initial anticoagulant developed and used in clinical care. Chart and diagram slides for powerpoint beautifully designed chart and diagram s for powerpoint with visually stunning graphics and animation effects. Anticoagulant, thrombolytic, and antiplatelet drugs katzung 9th ed. These drugs are used to treat strokes, myocardial infarctions, pulmonary embolisms.
If youre new here, you may want to subscribe to our rss feed. Anticoagulant, antithrombotic and antiplatelet drugs. In 1979, several groups were working toward the identification of the specific sequence of monosaccharides in heparin with high affinity for antithrombin at lindahl et al. Brahma department of pharmacology neigrihms, shillong 2.
Pharmacologyanticoagulants wikibooks, open books for an. Polymorphisms in vitamin k epoxide reductase gene and. Ppt anticoagulant drugs powerpoint presentation free. Principles of pharmacology, drug absorption and distribution, drug elimination and multiple dosing, clinical pharmacokinetics, drug metabolism, pharmacogenomics, drug toxicity, pharmacodynamics, drugs discovery and clinical trials. Ian baldwin, in critical care nephrology third edition, 2019. Dscontinue drug administration a dminister vitamin k 1 phytonadione and freshfrozen plasma or factor ix concentrates konyne80 and proplex which contained prothrombin complex.
Chapter 10 anticoagulant, anti platelet, and thrombolytic drugs. It is a racemic mixture of two optically active isomers r and s in equal proportion. Kd tripathi essentials of pharmacology free download pdf. You can use these pharmacology ppt in your projects and presentations. Chapter 8 drugs affecting the gastrointestinal system. No much effect on aptt than heparin less antiplatelet actionless thrombocytopenia less. Overview of the coagulation cascade and the targets of action for different novel oral anticoagulant agents. New oral anticoagulants noac watag guidelines scgh ed cme. Easily compare tier status for drugs in the same class when considering an alternative drug for your patient. The first paper entitled coumadin warfarin sodium a new anticoagulant was published in 1956. Apr 17, 2020 evaluation in various clinical trials new oral anticoagulant drugs noads have been vigorously evaluated in various largescale clinical trials.
When taking anticoagulant and antiplatelet drugs, follow the instructions your doctors instructions and call your doctor if you miss a. Find powerpoint presentations and slides using the power of, find free presentations research about classification of anticoagulants ppt. Coagulants, anticoagulants authorstream presentation. The focus of this chapter is on elements of anticoagulant clinical pharmacology that are important for anesthesiologists to understand. Warfarin is used as prophylaxis of venous thromboembolism in atrisk patients. Indications for anticoagulant and antiplatelet combined. Ivmscv pharmacology drugs affecting the blood authorstream. Anticoagulant therapy principles and practice of hospital. The risks and side effects of these drugs can be serious. Risk of bleeding is dependent on the class of anticoagulant agent used, patients age, and preexisting health conditions. Intrinsic pathway extrinsic pathway tissue injury blood vessel injury recall. Drugs used in disorders of coagulation, in basic and clinical pharmacology, katzung, b. Blood coagulation and anticoagulant, fibrinolytic, and antiplatelet.
Department of pharmacology university of michigan medical school mode of action of antiplatelet agents ticlopidine ticlid platelet inhibition is irreversible. The most serious and common adverse side effect associated with anticoagulant are increased risk of bleeding, both nonmajor and major bleeding events. Due to their mechanism of action, the new oral anticoagulants are named direct oral anticoagulants doacs. A power point presentation on the fundamentals of anticoagulant drugs suitable for ug level medical students. Warfarin is the oral anticoagulant with which clinicians have the most experience. For over 50 years, unfractionated heparin ufh and vitamin k antagonists vkas had been the primary anticoagulants prescribed in practice.
Critical facts if med school is a minnesota forest with millions of trees, these are the red pines 1. This is a ten question anticoagulant drugs quiz, one which is based off the content of this summary. Anticoagulants can be obtained naturally or derived synthetically. Anticoagulants are the cornerstone therapy for thrombosis prevention and treatment. In the fields of medicine, drug discovery is the process by which new candidate medications are discovered. Pharmacology hematologic drugs coagulation bleeding.
The pharmacological basis of therapeutics, e brunton ll, hilaldandan r, knollmann bc. Anticoagulant effect dependent on two considerations partially inhibited synthesis of the four vitamin kdependent clotting factors and naltered degradation rates of these factors. Ppt anticoagulant drugs powerpoint presentation free to. Ppt pharmacology powerpoint presentation free to view. Basic pharmacology anticoagulants limit the ability of the blood to clot venous thrombosis fibrin rich antiplatelet drugs limit the migration or aggregation of platelets arterial thrombosis platelet rich thrombolytics fibrinolytics drugs act to dissolve clots after they. Classification of antiplatelet drugs drug group sub groups route name of drugs 1 irreversible cox inhibitor oral aspirin low dose 2 adp receptor blockers p2y thienopyridines oral clopidogrel, prasugrel, ticlopidine, ticagrelor 3 glycoprotein iibiiia inhibitors monoclonal antibody iv abciximab peptide inhibitors iv eptifibatide, tirofiban 4. There are two main classes of anticoagulant drugs oral and injectable. Under normal circumstances, a delicate balance between coagulation and fibrinolysis prevents both thrombosis and hemorrhage.
Anticoagulants are usually administered to patients with myocardial infarction, venous thrombosis, peripheral arterial emboli and pulmonary emboli. Abnormal physiologic vitamin k control loop hereditary oral anticoagulant resistance most serious interaction. Anticoagulant, thrombolytic, and antiplatelet drugs. Anticoagulant medications have served as the principle therapy to prevent thrombosis for a variety of cardiovascular diseases over many years. Dabigatran is a selective, competitive, direct inhibitor of thrombin factor iia while. Pharmacology hematologic drugs free download as powerpoint presentation. While anticoagulants are commonly employed, their use is often associated with adverse drug events and increased readmission rates. Special attention should be given to patients needing a combination of an oral anticoagulant and an antiplatelet agent and efforts should be made to improve patients education to prevent them taking nonprescribed drugs. Antiplatelet, anticoagulant and thrombolytic drugs at. The drugs used in clotting and bleeding disorders fall into 2 major groups.
Guidelines for the use of oral anticoagulants cha 2 ds 2vasc score, see january c et al reference are based on various risk factors congestive heart failure, hypertension, age, diabetes, history of stroke, vascular disease, and sex. Some concomitant drugs may enhance the antithrombotic response, such as antiplatelet or nonsteroidal antiinflammatory drugs. Update on pharmacology of antiplatelets, anticoagulants. Clinical pharmacology of oral anticoagulants in patients. Common drug drug interactions are shown in table 3.
Goodman and gilmans manual of pharmacology and therapeutics, 2e hilaldandan r, brunton ll. Anticoagulant drugs prevent or delay formation of clot in the ec, and many methods are used with variability in the quality of evidence supporting their success and safety. Pharmacology and mechanisms of action of new oral anticoagulants. This book aims to explain how scientists unravel the many different ways medicines work in the body and how this information guides the hunt for drugs of the future. It is vital for the clinician who uses any of these anticoagulants to have a basic understanding of their pharmacology. Anticoagulant drugs pharmacology education project. Chapter 34 this version has been changed compared to the one made available on wednesday april 26 sorry. Winner of the standing ovation award for best powerpoint templates from presentations magazine.
Anticoagulants are drugs that treat blood clots, and help prevent blood clot formation in the veins and arteries. Anticoagulants, commonly referred to as blood thinners, are drugs that prevent or reduce coagulation of blood, prolonging the clotting time. From this group of drugs, warfarin is the drug of choice. Dabigatran, rivaroxaban and apixaban are oral anticoagulants which are alternatives to warfarin. Blood 2anticoagulant and procoagulant drugs authorstream. Our new crystalgraphics chart and diagram slides for powerpoint is a collection of over impressively designed datadriven chart and editable diagram s guaranteed to impress any audience. Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from. Set 1 powerpoint links collected from the website of. The major classes of anticoagulant drugs have distinctly different mechanisms of action, routes. Drug drug interactions and their effects on pharmacokinetics the pharmacokinetics of a drug can be modified considerably by concomitant medications. Brahma department of pharmacology neigrihms, shillong.
Anticoagulant, antithrombotic and anti platelet drugs. Blood coagulation and anticoagulant, fibrinolytic, and. Pharmacology is a broad discipline encompassing every aspect of the study of drugs, including their discovery and development and the testing of their action in the body. Anticoagulation drugs represent a rapidly expanding field, with many novel agents in various stages of testing and approval. Learn anticoagulant drugs pharmacology anticoagulants with free interactive flashcards. A new group of oral anticoagulants has emerged in the marketplace with a wide range of indications, creating more options for clinicians, but also more challenges in drug and patient selection. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. There are several different types of anticoagulant.